Calls to US poison centers involving kratom rose 1,200% between 2015 and 2025, according to the CDC. In Maine, physicians are now seeing more emergency visits tied to the unregulated, opioid-like substance. Even though The Pine Tree State features an abundance of inpatient programs and local Narcotics Anonymous chapters for residents, the kratom trend sits squarely inside the country’s wider struggle with opioid addiction.

The Numbers Behind Kratom

Kratom comes from a tree native to Southeast Asia and is sold as a powder, pill, or liquid, often at gas stations and convenience stores. Dr. Carin King Malley, an emergency physician at Maine Medical Center and a medical toxicologist with the Northern New England Poison Center, relayed that kratom-related calls and emergency room visits in the state have climbed over 50% in recent years, matched by more potent kratom variants.

The number meshes with other reports nationwide. Nationally, the CDC reported the 1,200% jump in poison-center calls over the past decade. Overdose deaths involving kratom are showing up across the country. In Florida, roughly 580 people died of kratom-related overdoses over 10 years. Many deaths also involved other drugs, including opioids, but in dozens of cases kratom was the only substance detected.

An Unregulated Supply Problem

Kratom isn’t regulated by the US Food and Drug Administration and is sold under many brand names. That includes products marketed as containing synthetically derived 7-OH, a far more powerful form akin to opioids. Malley reported that officials find it nearly impossible to know how concentrated any given product is because labeling requirements are minimal and what is on the package may not match what is inside.

Enforcement has struggled to keep pace. Malley noted that when some states have tried to ban one form of kratom, manufacturers simply change the formula and put the product back on shelves. For now, she observed, the best protection people have is accurate information about what they’re buying and knowing the signs of addiction.

Kratom and Its Opioid-Like Risks

Kratom is often marketed as an energy booster, mood lifter, pain reliever, and remedy for opioid withdrawal, though the Mayo Clinic calls it unsafe and ineffective. At higher doses its active compounds act on opioid receptors, which is part of why it can ease withdrawal for some people despite its opioid-like dangers. Malley warned that kratom can cause dependence, acute toxicity in large amounts, and withdrawal of its own. Purchasing it without a prescription doesn’t make it safe.

Harm Reduction & Treatment

Anyone using kratom or opioids can lower their risk by not using alone and by keeping naloxone on hand. Naloxone, sold as Narcan, can reverse an opioid overdose and is readily available without a prescription at most pharmacies. Because kratom-related overdoses often involve opioids, these steps apply here as well.

For people ready to stop, evidence-based treatment for opioid use disorder includes medication such as buprenorphine or methadone, combined with counseling. 

Peer support can help as well. NA meetings offer free and confidential fellowship in online and in-person formats. Attending your first NA meeting can open a door to lifelong healing and even friendships with colleagues who don’t judge.

Starting Out with NA

The Kratom crisis may be new, but NA has long stood ready to combat any form of narcotics dependency. If you live with opioid addiction or worry about kratom use, help is available and NA doesn’t require commitment to any single program. 

Our browsable directory can help you find NA meetings and opioid treatment options near you. For free and confidential referrals any time, dial 800-934-1582(Sponsored) and chat with a specialist.

A routine probation check in Southern California has again shown how counterfeit pills and fentanyl move through the illicit drug supply. Investigators in Ventura County uncovered about a pound of fentanyl and 85,000 counterfeit Adderall pills as part of a seizure officials valued at roughly $2.1 million. 

The news has caught many residents by surprise. Simi Valley enjoys a reputation for its safe suburbs. The Golden State offers many programs to help those impacted by substance misuse, including local Narcotics Anonymous chapters at the community level. But for families already affected by the opioid crisis, the case somberly reminds us that pills bought outside a pharmacy often aren’t what they look like.

The Seizure in SoCal

According to the Simi Valley Police Department, officers contacted two people during a probation check. When they arrived, the officers found roughly two kilograms of ketamine and about $8,000 in cash in a vehicle. 

Search warrants for a San Clemente home and several storage units followed. Investigators reported seizing 85,000 counterfeit Adderall pills, 25,000 ecstasy pills, about 30 pounds of ketamine, one pound of fentanyl, seven pounds of cocaine and 10 pounds of psilocybin and other hallucinogens. 

Authorities arrested two people. The investigation, now spanning three counties, remains active.

Counterfeit Pills are Dangerous

Fentanyl is a synthetic opioid, in which a very small amount is fatal. The counterfeit pills seized here matter because fake prescription tablets, sold as Adderall, oxycodone, or Xanax, are frequently pressed with fentanyl. A person may believe they’re taking a familiar prescription drug and have no way to know a pill contains a lethal dose. This is a central driver of overdose deaths across the country.

Harm Reduction & Treatment

Two tools save lives here. Naloxone, also sold as Narcan, can reverse an opioid overdose within minutes and is available without a prescription in most states. Fentanyl test strips let people check whether a substance contains fentanyl. Neither replaces treatment, but both keep people alive long enough to seek it. 

For opioid use disorder, medication-assisted treatment with buprenorphine or methadone is the standard of care and can be paired with counseling and peer support.

Finding a First Step to Defeat Opioid Addiction

Support is available whether someone wants treatment, peer community, or both. Narcotics Anonymous meetings offer free, judgment-free peer support and are held in person and online nationwide. 

Getting started with NA is easy. Simply browse our directory, organized by state and city. You can also dial 800-934-1582(Sponsored) to speak with an expert and connect with opioid treatment options. If an overdose is happening, call 911 immediately.

A substance once marketed as a natural remedy is drawing federal action and personal warnings from the people who used it. Current and former users described kratom and its derivatives, especially its concentrated compound 7-hydroxymitragynine, or 7-OH, as an addictive substance like opioids that upended their lives. 

Their accounts line up with what regulators and researchers now document about opioid addiction risk. Side effects range from dizziness to comas tied to these products.

## Understanding Kratom & 7-OH

Kratom comes from the leaves of Mitragyna speciosa, a tree native to Southeast Asia, and has traditionally been used as a tea or chewed leaf. Its main active compounds, mitragynine and 7-OH, act as partial agonists at the brain’s mu-opioid receptors, the same receptors targeted by opioids like morphine and heroin. That’s why kratom produces pain relief and a sense of euphoria and often leads to dependence.

The bigger concern for 7-OH relates to the substance’s concentrated or semisynthetic form. According to the FDA, 7-OH binds opioid receptors and carries real potential for abuse. Preclinical data cited by federal regulators put its abuse potential in the range of Schedule I and II opioids such as fentanyl.

The CDC reported that kratom-related exposures at US poison centers rose roughly 1,200% from 2015 to record levels in 2025. That spike lines up with the arrival of high-potency, semisynthetic 7-OH products. National data show lifetime kratom use grew from about 4 million to 5 million people, meaning more people try it.

Regulators and Harm Reduction

In late 2025, the FDA warned that kratom can’t be legally sold in the United States as a drug, food additive or dietary supplement. In July 2026, the Drug Enforcement Administration issued notices of intent to temporarily place 7-OH and three related synthetic compounds into Schedule I of the Controlled Substances Act. It’s the same category as heroin. 

The FDA emphasized that its action targets concentrated 7-OH products, not the traditional kratom leaf. These products are widely sold in gas stations, smoke shops, and convenience stores. At times, consumers buy kratom in candy-like formats that raise added concern for young people.

Since 7-OH acts on opioid receptors, the same overdose precautions that apply to opioids apply here. Naloxone, the overdose-reversal medication, can counter opioid effects. Authorities recommend keeping naloxone on hand for anyone at risk. Signs of opioid overdose include slowed or stopped breathing, unresponsiveness and blue-tinged lips or fingertips; call 911 immediately.

For people who develop kratom or opioid dependence, treatment works. Medication for opioid use disorder, including buprenorphine, has successfully managed kratom use disorder and ease withdrawal. Furthermore, counseling, medical support and peer recovery groups all have a place in recovery. 

Narcotics Anonymous meetings offer free peer support for people addressing drug use of any kind, and they can complement medical treatment rather than compete with it.

NA Fights Opioid Addiction

If kratom or another opioid has become hard to control, take the next steps. The easiest and simplest—and free—is to find a local NA chapter. In addition, participants find that all meetings confidential, and online options exist if transportation is an obstacle.

To get started, simply call 800-934-1582(Sponsored) or browse our directory for chapters across the country.

A single traffic stop in southern Utah pulled an estimated 330,000 fentanyl pills off the road. This seizure shows how much of the synthetic opioid is still moving through communities during the overdose epidemic.

Even though Utah features a wide range of inpatient programs and local grassroots such as Narcotics Anonymous chapters for folks impacted by substance abuse, the influx of illegal drugs continues to drive the crisis in the Beehive State. In this instance, the pills carried an estimated street value of about $3 million, according to the San Juan County Sheriff’s Office.

Arrests in Monticello

A San Juan County deputy stopped a car for speeding in Monticello on July 1. After the people inside gave what the deputy described as inconsistent accounts, and with their consent to search, the deputy found roughly 330,000 fentanyl pills hidden in the spare tire compartment. 

Two people, ages 25 and 57, were arrested and booked into the county jail on a first-degree felony charge of fentanyl trafficking along with misdemeanor counts. The charges are allegations, and the investigation is ongoing.

As new opioids spring up in the streets, perpetuating the crisis, the traffic stop is a somber reminder of how deep illegal drugs have penetrated communities. 

Fentanyl and the Overdose Epidemic

Fentanyl is a synthetic opioid many times more powerful than other opioids, and just a very small amount can be fatal. Much of it now reaches people in counterfeit pills made to look like legitimate medication and mixed with other street drugs, which means someone may take a dangerous dose without knowing it. 

Law enforcement agencies have warned that some pills also contain carfentanil or heroin, raising the danger further.

Harm Reduction Saves Lives

Opioid use disorder is a treatable medical condition, not a moral failing. Medication-assisted treatment uses medications such as buprenorphine, methadone or naltrexone alongside counseling to reduce cravings and support recovery. 

Peer support, including Narcotics Anonymous meetings, can add community and accountability for people working toward and maintaining recovery.

Practical steps that reduce overdose risk:

• Carry naloxone, sold as Narcan, which can reverse an opioid overdose
• Use fentanyl test strips to check for the drug before use
• Never use alone, so someone can call for help
• Call 911 right away if you suspect an overdose

Get Help for Opioid Addiction

We can help people find opioid treatment programs and NA meetings nearby. Just browse our directory to find verified meeting chapters anywhere in the nation. 

You can also call 800-934-1582(Sponsored) to speak with an expert about harm reduction resources such as naloxone access and fentanyl test strips.

A veterinary sedative powerful enough to immobilize a rhinoceros has moved into the U.S. fentanyl supply, and federal health agencies say it makes overdoses harder to reverse. On April 2, 2026, the CDC and the White House Office of National Drug Control Policy issued a joint health advisory warning that medetomidine has rapidly displaced xylazine as the dominant sedative mixed into illicit fentanyl.

For individuals who use opioids and the families who love them, the change carries a hard message. Harm reduction still works, but it can’t reverse everything now found in the fentanyl supply, including mixed polysubstances.

A More Potent Successor to Xylazine

Medetomidine, known on the street as rhino tranq, belongs to the same drug class as xylazine, the sedative that became known as tranq dope. But it’s far stronger. The advisory describes medetomidine as up to 100-200x more powerful than xylazine. Tranq produces deep sedation, a dangerously slowed heart rate, and very low blood pressure that can last for hours after the fentanyl wears off.

Naloxone, sold as Narcan, reverses opioid overdoses by knocking opioids off their receptors in the brain. Medetomidine works on a different system, so naloxone has no effect on it. First responders are finding people who stay deeply unconscious even after several doses of naloxone have restored their breathing.

The CDC still urges anyone responding to a suspected overdose to give naloxone right away for the opioid. Then, call 911 because the person may need breathing and heart support for an extended period.

The Numbers Behind the Surge

The shift has been fast. Medetomidine detections rose from 247 cases in 2023 to 8,233 in 2025, an increase of more than 3,000% in two years. The drug has turned up in at least 18 states, with the highest concentrations in the Northeastern areas like New York and the Midwest. At eight sentinel drug-testing sites, tranq appeared in more than half of opioid-positive samples, while xylazine detections have begun to fall.

The risk doesn’t end with the overdose. People who use medetomidine regularly can develop a severe withdrawal that resembles clonidine withdrawal, with sharp spikes in blood pressure, intense anxiety, nausea and fluctuating consciousness that may require emergency care. Dr. Colleen Huzinec, a clinical pharmacist who specializes in toxicology, reported how “the sedation is deeper, the cardiovascular effects are more severe.”

Harm Reduction & Treatment

Fentanyl remains dangerous; it’s still the primary cause of overdose deaths, so carrying and using naloxone is still essential. Harm reduction groups note that xylazine test strips can offer false reassurance by detecting a declining threat while missing the rising one. 

These developments come as national overdose deaths have fallen 50% since 2023. But public health officials say this trend remains fragile. New addictions like tranq threaten to undo that progress.

If you or someone you know is living with opioid use disorder, support is available through Narcotics Anonymous meetings, medication-assisted treatment such as methadone or buprenorphine, and local harm reduction services that distribute naloxone.

Starting with NA

Prolonged unconsciousness despite normal breathing may signal a sedative like medetomidine. For those who do take drugs, avoid using alone whenever possible.

Starting recovery is never easy. But help exists, right in your own neighborhood. By enrolling in a local Narcotics Anonymous chapter, you can meet peers who understand your experience and empathize with you. This lifelong fellowship sustains recovery and remains confidential and free.

To find NA meetings and opioid treatment options near you, call 800-934-1582(Sponsored) . You can also browse our directory for NA chapters across the nation.

Spokane County has lost a local resident to an overdose nearly every day for two years running. The number of deaths is driven by the fentanyl that now dominates the local drug supply. Against that backdrop, one woman who survived a fentanyl overdose is showing what opioid addiction recovery can look like and why access to treatment and harm reduction matters.

To be clear, Washington offers an abundance of programs for substance use disorders. The Evergreen State features local Narcotics Anonymous chapters all the way up to modern inpatient facilities. Nevertheless, vulnerable populations fall through the cracks, and this is where Victoria Neumiller found purpose.

Neumiller woke from a fentanyl overdose near a Spokane convenience store five years ago, revived by friends using ice because they had no other tool at the time. Today she is about three years into recovery and works at a stabilization center helping others through withdrawal.

The Opioid Crisis in Spokane

Spokane County recorded 344 overdose deaths in 2025 and 346 in 2024. That’s roughly fourfold the 80 deaths in 2019, when fentanyl took hold in the Inland Northwest.

In 2025, the Spokane Fire Department responded to 1,795 patients who’ve overdosed and administered the overdose-reversal medication Narcan 980 times. That’s an average of about 150 overdose responses and 82 Narcan uses a month in the city alone.

Understanding Fentanyl and Overdose

Fentanyl is a synthetic opioid far more potent than other street drugs, which makes overdoses more frequent and harder to reverse. Naloxone, often sold as Narcan, can restore breathing during an opioid overdose by blocking opioids in the brain, and it often takes more than one dose against fentanyl. 

An overdose can consist of slowed or stopped breathing, blue lips, and unresponsiveness. Calling 911 can save a life.

Neumiller’s path ran from cocaine in her teens through methamphetamine and heroin to fentanyl, a progression all too common as tolerance builds. She has been in recovery from all substances since an arrest in 2023 that she describes as the turning point.

Harm Reduction & Treatment

Neumiller credits a mix of support for helping her get and stay in recovery: an Oxford House, stabilization centers, employment and family. Now she helps people through the sweats, nausea, and insomnia of opioid withdrawal at the Pioneer Human Services Stabilization Center. About 40 people come through for help on a given day.

No single path works for everyone. Medication-assisted treatment via FDA-approved prescriptions, medically supervised detox, peer support, and mutual-aid groups all have a role. As Neumiller put it, someone might go through treatment many times before the attempt that finally holds.

Help for Opioid Addiction in Washington and Beyond

If you or someone you love is facing opioid or fentanyl use, there are next steps available right now.

The easiest and most common way is to join a local Narcotics Anonymous chapter in your neighborhood. NA meetings are free to participate, confidential, and made up of peers from your community. Simply dial 800-934-1582(Sponsored) to chat with a specialist or look through our online directory for meetings anywhere in the country.

Nearly half of the people who died of a drug overdose in Indiana had recently filled a prescription for a controlled medication. This finding points to missed chances to reach people living with opioid addiction. The data comes from a new Indiana Department of Health report covering 2022 through 2024.

The Hoosier State boasts many programs for those impacted by substance abuse, from local Narcotics Anonymous chapters to modern inpatient facilities. Still, many people, especially mothers, fall through the cracks. For families and clinicians, the takeaway is hopeful in one sense. Many victims were in contact with the health care system not long before they died. Each of those contacts is a chance to step in.

The Opioid Crisis Among Hoosiers

The state linked death records to its prescription monitoring database, INSPECT, and reviewed 6,549 overdose deaths. It found that 47% of those who died had filled a prescription for a controlled opioid, benzodiazepine, or stimulant within the year before death.

The timing was tight. Among people who had a controlled prescription, 67% had filled it within 90 days of their fatal overdose. State health officials describe that narrow window as a high-stakes opportunity for providers to intervene.

The Prescription Data

Among those who filled a controlled prescription in their final year, 58% received opioids, 36% got benzodiazepines, 36% received buprenorphine as a medication for opioid use disorder, and 11% had stimulants. More than 35% were prescribed more than one drug class at the same time, with the most common pairing being opioid pain relievers with benzodiazepines at 39%.

Measured by how often medications were dispensed, buprenorphine was actually the single most commonly filled controlled substance (40.2%), followed by oxycodone and hydrocodone. 

That reflects how clinicians refilled buprenorphine for folks in ongoing treatment, not that the medication causes overdoses. Medication-assisted treatment (MAT) is an evidence-based treatment that lowers overdose risk; its frequent appearance here signals how many people participated with care.

Across every drug class the state looked at, the median time between the last prescription pickup and death was under two months.

Opioids, Overdose  What to Do About It

Opioids include prescription pain medications, as well as illicit drugs like heroin and illegally made fentanyl. Fentanyl is a synthetic opioid far stronger than heroin and now drives much of the overdose crisis. Mixing opioids with benzodiazepines is especially risky because both slow breathing, which raises the chance of a fatal overdose.

The state urges clinicians to follow CDC prescribing guidance and screen patients for mental health conditions. Officials also advocate for naloxone, popularly known as Narcan, to people at risk, especially anyone taking opioids and benzodiazepines together. Naloxone can rapidly reverse an opioid overdose and is available without a prescription in most places.

For people living with opioid addiction, MAT is among the most effective options and is supported by strong evidence. Peer support through Narcotics Anonymous helps many people as well. These paths don’t compete, as people often combine medication, therapy and regularly attend NA meetings.

Help for Opioid Addiction in Indiana

When substance dependency takes hold, life often becomes a cycle of violence and despair. But there’s always hope, no matter your background or life circumstances. Enrolling in NA is often the first step towards a long recovery. Meetings are free, confidential, and attended by your peers.

Call 800-934-1582(Sponsored) to speak with a specialist, or browse our directory for NA chapters anywhere in the USA.

Folks living with opioid addiction face a danger many never expected, that of lethal fungal infections inside the same needles used to deliver their doses. A new university study based in Ohio has found that the illicit drug supply fueling the opioid crisis had contaminates far more than narcotics.

Residents out in Ohio have a wide variety of programs to combat substance misuse. From small Narcotics Anonymous chapters to large and modern inpatient care centers, The Buckeye State can help folks no matter their background. However, new developments like fungi complicate treatment programs for many.

The Opioid Crisis Across the County

Researchers at Bowling Green State University worked with the Toledo Lucas County Health Department to analyze used hypodermic needles collected through a local needle exchange program. 

The results took them by surprise. The average needle tested contained eight different compounds. Even worse, 86% of the needles carried xylazine. This is a powerful veterinary tranquilizer increasingly mixed into street drugs. The team also discovered a dangerous fungal pathogen called Candida in the used needles. 

The findings arrive against a grim national backdrop. More than 100,000 Americans have died annually since 2021 from intravenous drug use. Furthermore, fungal infections already claim roughly two million lives worldwide each year and climbing.

Driving the Trend

With reports of new synthetic drugs in the streets, the study initially set out to answer a basic question: what is actually in the drug supply driving narcotic addiction in northwest Ohio? Lead researcher Dr. Hans Wildschutte originally expected to find bacteria in the samples, not a fungus capable of life-threatening bloodstream infections. 

Coming into contact with Candida can lead to serious illness. Doctoral student Nara Souza noted that fungal infections are especially hard to treat because antifungal medications are limited or toxic. Diagnostic testing also takes longer than it does for bacterial infections. 

In an unexpected twist, the team also identified a soil-based bacterium called Pseudomonas that killed Candida in lab testing. This discovery can open a new path toward antifungal drug development for people affected by intravenous drug use.

Fentanyl’s Role in the Opioid Crisis

Opioids are a class of narcotic drugs, including heroin and prescription painkillers, that bind to receptors in the brain to relieve pain and produce euphoria. Fentanyl especially remains the single biggest driver of overdose deaths nationwide. But this study underscores how the broader opioid crisis has evolved beyond fentanyl alone. 

Xylazine is often called “tranq” and doesn’t respond to naloxone the way opioids do. This means a person who has used fentanyl or other narcotics cut with xylazine may need additional medical support during an overdose. The researchers also witnessed the presence of multiple unknown compounds in a single dose. These polysubstance doses make opioid abuse increasingly unpredictable and dangerous, even for people who believe they know what they are using.

Harm Reduction and Treatment for Opioid Addiction

Public health experts continue to emphasize harm reduction alongside long-term treatment. Naloxone access, fentanyl test strips and needle exchange programs like the one that made this research possible all reduce immediate health risks for people who use drugs. 

An opioid overdose slows or stops breathing, but naloxone can rapidly reverse those effects if administered in time.

Medication-assisted treatment remains among the most effective tools for treating opioid use disorder. 

Peer support through Narcotics Anonymous and other NA meetings also plays a critical role in long-term recovery, giving folks struggling with narcotic addiction a community of others who understand the path forward.

Help for Opioid Addiction

Intravenous drug use takes place across the country. For those impacted, enrolling in NA is often the first step. Meet your peers in your community and form fellowships that last a lifetime. Browse our listings for NA chapters anywhere in the country or call 800-934-1582(Sponsored) for opioid addiction treatment options.

The advanced AI screening tools doctors and pharmacies rely on to identify patients at risk of opioid addiction may be doing more harm than good. AI has flagged the wrong people while missing thousands who genuinely need help.

A landmark new study found that AI-powered opioid risk scoring systems produce false positives at an alarming rate. The report raises urgent questions for patients, providers and anyone affected by the opioid epidemic.

Opioid Addiction Risk Tools are Failing Patients

Artificial intelligence tools like NarxCare and Epic scan electronic health records and prescription drug databases to generate Opioid Risk Scores (ORS) for patients. The AI shares these results with healthcare providers so that they can flag those considered at risk of opioid misuse or overdose. Patients flagged as high risk may be denied opioid prescriptions or dropped from care entirely. 

But this new study suggests that using opioid risk scores to predict patient behavior has major flaws. The study indicated that the system produced unacceptably high rates of false positives.

For the millions of Americans living with opioid addiction or managing chronic pain with prescription opioids, that’s not an abstract research finding. It can mean being cut off from legitimate medication, labeled a drug-seeker, or pushed out of the healthcare system entirely. All these scenarios can paradoxically increase overdose risk.

The Opioid Crisis

The study examined Epic’s opioid risk scores for 700,000+ American patients treated by primary care providers. Epic scored 99.6% as low risk, with only 0.4% flagged as high risk.

The accuracy gap between those two groups is stark. Of the 2,665 patients classified as high risk, only 185 received an overdose or opioid use disorder diagnosis. This indicates that Epic’s scoring system was accurate only 7% of the time. Conversely, it produced a false positive rate of 92.2%.

Lead researcher Dr. Stephanie Hooker of the HealthPartners Institute wrote that the tool’s misclassification rate “could undermine its external validity, leading to misallocated resources and missed interventions.”

The low-risk category isn’t clean either. Of the 2,362 patients who ultimately experienced an overdose or opioid use disorder diagnosis, Epic’s system had flagged only 185 as high risk. The numbers suggest more than 2,000 patients were incorrectly labeled as low risk.

The Problem’s Core

The tools aren’t just inaccurate. They might measure the wrong things entirely. Pain management expert Dr. Lynn Webster is a Senior Fellow at the Center for U.S. Policy and explains it’s a mistake to count diagnoses and overdoses in the same predictive model because they’re distinct events. Someone can overdose without having a diagnosis and vice versa.

“Opioid risk tools will always struggle to predict overdose death risk because overdoses can occur in patients who have no opioid use disorder and no aberrant drug-related behavior,” Webster relayed. “Some patients overdose even when they take their medications exactly as prescribed.”

The stakes are high because these systems are everywhere. Epic’s MyChart software has already collected data on 190 million patients. Major pharmacies like CVS and WalMart use NarxCare for their customers.

Flawed Scoring Deepens the Opioid Epidemic

Inaccurate risk tools may actively worsen the opioid epidemic by pushing people toward unregulated street drugs like heroin. When patients with legitimate opioid addiction or pain conditions are denied prescriptions or abandoned by their doctors, some turn to the illicit market, where new synthetic drugs like orphines have made overdose deaths much more likely.

Webster warns that both NarxCare and Epic scores “can be harmful if used punitively.” The overestimated risk can lead to forced tapering, patient abandonment that “paradoxically increase overdose risk.” Once a risk label enters a patient’s chart, “it can take on a false authority that changes how patients are treated.” 

For families navigating the opioid crisis, this means a loved one with a narcotic addiction could be quietly flagged, stigmatized, and shut out of care, with no way to appeal an algorithm’s judgment.

Opioid Use Disorder and Overdose Risk

Opioid use disorder is a chronic condition characterized by compulsive opioid use despite harmful consequences. It encompasses addiction to prescription opioids and illicit fentanyl, the latter is responsible for the majority of U.S. overdose deaths. 

Naloxone (Narcan) can reverse an opioid overdose when administered quickly and is available without a prescription in most states. Still, experts warn that naloxone might not be enough to reverse overdoses caused by polysubstance abuse, which consists of two or more opioids mixed together.

Harm Reduction & Treatment Options

Knowing the difference between physical dependence, addiction, and overdose risk is critical But AI tools appear to blur all three.

Even if AI has a long way to go, that doesn’t mean you should sit on the sidelines. Whether or not a risk tool has flagged you, effective opioid addiction treatment is available. Evidence-based options include:

• Medication-assisted treatment (MAT): Medications like buprenorphine and methadone are FDA-approved for opioid use disorder and significantly reduce overdose risk. 

• Naloxone/Narcan: Anyone at risk of opioid overdose should have naloxone on hand. Many pharmacies now carry it without a prescription, and many health departments distribute it for free.

• Fentanyl test strips: Because fentanyl contamination in the illicit drug supply is widespread, fentanyl test strips are a critical harm reduction tool. Check with your local health department for free distribution programs.

Peer support remains one of the most powerful tools in opioid addiction recovery. Narcotics Anonymous (NA) meetings are free, widely available, and welcoming to anyone struggling with narcotic addiction.

AI is new and can assist clinicians, but fellowship with peers is tangible, real, and lasts a lifetime. Call 800-934-1582(Sponsored) or browse our directory to find NA chapters anywhere in the U.S.

Officials have uncovered a new synthetic opioid stronger than fentanyl spreading through the illicit drug supply and killing people before many communities even know it exists. The opioid crisis now has a new front-line threat: cychlorphine, a powerful synthetic orphine. Federal officials now sound the alarm for the first time with an emergency drug threat notice.

The White House Office of National Drug Control Policy (ONDCP) issued its first official Drug Threat Notice to warn law enforcement, public health officials, and medical providers about the spread of cychlorphine. Cychlorphine is linked to at least 55 deaths nationwide between 2025 and 2026. For anyone with opioid addiction or for families worried about a loved one, this is a development that demands immediate attention.

The Opioid Crisis Thus Far

Cychlorphine’s formal name is N-Propionitrile Chlorphine and has been detected in the illicit drug supply across 10 states, with the highest concentrations reported in Ohio, Texas, and Tennessee. The Knox County Regional Forensic Center in Tennessee linked the substance to at least 41 fatalities between July 2025 and February 2026 alone.

Those numbers, while devastating, almost certainly undercount the true toll, given cychlorphine’s near-invisibility in standard screening.

Cychlorphine is More Dangerous Than Fentanyl

ONDCP warned that cychlorphine has up to 10x the potency than fentanyl, and overdoses may require multiple doses of naloxone to reverse. Officials also noted the drug is especially difficult to detect because it doesn’t appear on common test strips or hospital opioid urine screenings.

That last detail is critical for anyone in recovery or anyone who uses fentanyl test strips as a harm reduction measure: those strips will not detect cychlorphine. This is a fundamental shift in the opioid crisis landscape that affects not just people actively using substances, but emergency responders, family members carrying naloxone, and treatment providers.

Officials have found cychlorphine mixed with fentanyl, methamphetamine, cocaine, bromazolam, and other illicit substances in addition to pure samples. The opioid belongs to a class of synthetic orphines that include brorphine, chlorphine and spirochlorphine.

Synthetic Opioids and Overdose Risk

Synthetic opioids are man-made substances designed to mimic the effects of naturally derived opioids like heroin or morphine but are engineered to be far more potent. Fentanyl has long been the dominant driver of overdose deaths in the United States and is itself a synthetic opioid roughly 100x more potent than morphine.

The emergence of cychlorphine doesn’t mean fentanyl has receded. In fact, cychlorphine has been found mixed with fentanyl and even vapes. A person who believes they’re using one substance may unknowingly encounter two deadly synthetic opioids simultaneously. Poly-drug combos dramatically increase overdose lethality and complicate emergency response.

ONDCP urged EMS personnel, clinicians, law enforcement and the public to be aware of the drug’s growing presence, prepare for more severe overdose responses and seek immediate medical care in suspected overdose cases.

The White House’s Response

The warning comes just weeks after ONDCP released the 2026 National Drug Control Strategy. This sweeping federal roadmap will disrupt illicit drug trafficking, target transnational criminal organizations and improve detection of emerging synthetic drug threats. Released May 4 by ONDCP Director Sara Carter, the strategy calls for expanded advanced technology to identify evolving drug threats. The program will increase intelligence-driven interdictions of precursor chemicals and nationwide wastewater testing to provide near real-time data on illegal drug trends.

The new Drug Threat Notices can at least inform communities and frontline responders about emerging substances before they become more widespread.

Harm Reduction and Treatment for Opioid Addiction

If you or someone you love has a narcotic addiction, don’t wait and see. The opioid crisis has evolved faster than individual awareness, and professional treatment saves lives.

• Naloxone / Narcan: Given that cychlorphine may require multiple doses, anyone at risk or near someone at risk should carry naloxone and know how to administer doses while calling 911. Narcan nasal spray is available without a prescription, and many local health departments distribute it for free.

• Medication-assisted treatment (MAT): Evidence-based opioid addiction treatment, including buprenorphine, methadone, and naltrexone, dramatically reduces overdose death risk.

• Narcotics Anonymous (NA) Meetings: Peer support through Narcotics Anonymous is a proven component of long-term recovery from narcotic addiction. NA meetings exist in nearly every city and town in the country, in-person and online.

Locate Narcotics Anonymous meetings in any location across the country. Peer support and community resources comprise an effective first and lasting step to overcoming substance use disorders. Search our directory or call 800-934-1582(Sponsored) to find options in multiple formats