Author: Hannah Sumpter

Oxycodone is an opioid painkiller prescribed for the management of moderate to severe pain.¹ When taken exactly as directed by your doctor, oxycodone is a therapeutic medication, but it has a high potential for harmful side effects, abuse, dependence and addiction.²

In this article: 

• What is Oxycodone Used For?
• Oxycodone Side Effects
• Oxycodone Contraindications
• Oxycodone and Addiction
• Signs and Symptoms of Oxycodone Addiction
• Risk of Oxycodone Addiction
• Treatment for Oxycodone Addiction

What is Oxycodone Used For

Initially, oxycodone was approved to treat severe pain, particularly post-operative.  But since its approval, other forms of oxycodone have been developed, including the extended-release tablet, OxyContin, and combination medications such as Percocet, which contain oxycodone and acetaminophen. These newer formulations are often used as long-term opioid treatment in which non-opioid painkillers are insufficient.^1,2

With this progress in pain-management efficacy, oxycodone is now commonly prescribed for the following:¹

• Postoperative pain
• Cancer pain
• Severe chronic pain
• Severe acute pain

According to the Centers for Disease Control, in 2023, approximately 125 million opioid prescriptions were dispensed to American patients. In that same year, nearly 8.6 million Americans 12 years and older reported misusing prescription opioids. 

Oxycodone Side Effects

As with all opioid medications, you may experience unpleasant side effects when taking oxycodone. The risk of experiencing oxycodone side effects increases if you misuse or abuse oxycodone. Examples of misuse and abuse include:

• Taking higher doses of oxycodone than prescribed
• Taking more frequent doses than prescribed
• Combining oxycodone with other substances, such as alcohol
• Using oxycodone in a way other than directed (crushing and snorting or injecting)

The most common side effects of oxycodone use include:^2,4

• Headache
• Dry mouth
• Nausea and vomiting
• Excessive sweating
• Sleepiness
• Dizziness
• Constipation
• Physical weakness or lack of energy
• Itchiness

Other possible side effects of oxycodone use may include:²

• Low blood pressure or slow heart rate
• Heart palpitations
• Photosensitivity
• Rash
• Stomach pain
• Inflammation of the tongue
• Confusion
• Hallucinations
• Seizures
• Irritability
• Respiratory depression

Most side effects from the medical use of oxycodone are mild and are not life-threatening. They will often decrease over time as your body adjusts to the medication, but sometimes an adjustment in oxycodone dosage is needed.² Conversely, if you misuse or abuse oxycodone, you may be at an increased risk of experiencing dangerous side effects and consequences, such as an overdose.

If you are experiencing any oxycodone side effects, speak with your medical provider so they can review the amount of oxycodone you are taking and potentially decrease the dose to make you more comfortable.

Oxycodone Contradictions

Caution should be taken before initiating oxycodone therapy, as it is contraindicated for individuals with certain medical conditions. 

If your medical provider has recommended you take oxycodone, please make sure you’re upfront about your medical history and other medication use to ensure that it is safe for you to begin taking oxycodone.

Oxycodone therapy is not recommended for patients with:²

• Respiratory depression
• Asthma (in unmonitored settings)
• Known or suspected bowel obstruction
• Certain blood conditions
• Those who are pregnant
• Previous severe reaction to opioids

Oxycodone and Pregnancy

Oxycodone has been given a black box warning for those who are pregnant. With this warning, medical professionals are advised to be extremely cautious when prescribing a medication to those who are or may be pregnant, as oxycodone can affect the developing fetus.² Studies have shown that oxycodone use during pregnancy may contribute to early delivery and birth defects, as well as negatively impact the baby’s overall development.²

Additionally, babies born to mothers who are taking opioids are at a greater risk of experiencing opioid withdrawal, or neonatal abstinence syndrome, at birth. Neonatal abstinence syndrome refers to a postnatal withdrawal experience, as the infant detoxes from opioids after birth.⁵

Symptoms of neonatal abstinence syndrome range from mild to severe and may include:⁵

• Tremors
• Irritability
• Fever
• Excessive weight loss
• Seizures

Symptoms of withdrawal typically begin within the first few days of birth, but can occur later on as well. The severity of withdrawal appears to be dose-dependent, meaning higher intensity opioid use during pregnancy results in more severe symptoms and withdrawal for the infant.⁵ Infants experiencing neonatal abstinence syndrome typically require intensive care for 24- to 48- hours or more.⁵

If you are currently taking oxycodone and are planning to become pregnant or think you are currently pregnant, please speak with your medical provider to discontinue oxycodone use and find a safer option for your pain management.²

Oxycodone and Addiction

Before beginning oxycodone use, you should be aware of its high addiction potential.

One reason it carries such a high potential for addiction is due to the sense of euphoria and relaxation it provides. For this reason, prescribers should closely monitor their patients for signs of dependence or addiction. 

 If you or a family member has a history of substance use disorder, it may be wise to try other forms of pain management.  

Signs and Symptoms of Oxycodone Addiction

Oxycodone addiction is a chronic, relapsing condition in which a person cannot control their use and continues to use regardless of negative consequences. Addiction is seen more often in people who are misusing this opioid painkiller, with or without a prescription, with the intent of seeking a high.

If a person is struggling with oxycodone addiction, they may exhibit some of these symptoms of addiction:⁷

• Oxycodone is often taken in larger amounts or over a longer period than intended.
• There is a persistent desire or unsuccessful efforts to cut down or control oxycodone use.
• A great deal of time is spent obtaining oxycodone, using oxycodone or recovering from its effects.
• Craving, or a strong desire to use oxycodone
• Recurrent oxycodone use that results in failing to fulfill major role obligations at work, school or home
• Continued oxycodone use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of opioids
• Giving up important social, occupational or recreational activities
• Recurrent oxycodone use in situations in which it is physically hazardous
• Continued use despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by oxycodone
• Tolerance, meaning you need higher doses to achieve the desired effect
• Withdrawal, meaning you need to take oxycodone to avoid withdrawal symptoms

If you are concerned that you or someone you know is addicted to oxycodone, help is available. Call 800-934-1582(Sponsored) to learn more about treatment options.

If you are taking oxycodone as prescribed by a doctor, you may develop tolerance and dependence. These are natural physiological adaptations that occur from continued use and do not necessarily mean that you have an oxycodone addiction. An addiction constitutes compulsive, uncontrollable oxycodone use that tends to worsen over time.

Risk of Oxycodone Addiction

Anyone who misuses or abuses oxycodone and other substances is at risk of developing an oxycodone addiction. However, certain risk factors increase a person’s chance of developing an addiction, including:⁸

• Aggressive childhood behavior
• Lack of parental supervision
• Drug availability
• Poverty
• Substance abuse
• Low peer refusal skills
• Parents or family members with drug addictions
• Parents or family members with legal problems
• Academic problems
• Poor social skills
• Physical or sexual abuse
• Mental health conditions

According to research, the earlier a person starts using drugs like oxycodone, the more likely they are to develop an addiction. Furthermore, how you use oxycodone affects your risk of an oxycodone addiction—if you snort, smoke, or inject oxycodone, you may be at an increased risk.⁸

Genes also play a role in the development of oxycodone addiction. It is estimated that genes account for about 40 percent to 60 percent of an individual’s risk of a substance use disorder.⁸

Treatment for Oxycodone Addiction

Beginning treatment for an oxycodone addiction can feel intimidating, but there are many safe and effective options to help you overcome your addiction and seek long-term sobriety.

Oxycodone Detox

If you have an oxycodone addiction, it is important to seek out professional help before discontinuing the medication. When you abruptly quit using opioids, such as oxycodone, you are likely to experience unpleasant and painful withdrawal symptoms. These can be distressing enough that you may return to oxycodone use to alleviate them. A professional detox program can provide you with the medical care needed to keep you safe and comfortable during withdrawal.

Typically, opioid detox will involve opioid withdrawal medications that can ease your symptoms and cravings. These medications include:⁹

• Methadone: A long-lasting opioid withdrawal medication, methadone is a full opioid agonist that alleviates oxycodone withdrawal symptoms without causing a high.
• Buprenorphine: A partial opioid agonist that eases uncomfortable symptoms without causing an opioid high.

Inpatient and Outpatient Treatment

Once you are medically stabilized and the oxycodone has cleared from your body, a treatment specialist will educate you on the benefits of transitioning into an oxycodone abuse treatment program. Oxycodone addiction treatment includes inpatient or outpatient options, with inpatient treatment being the more intensive form of treatment.

Inpatient addiction treatment is typically offered in a hospital or treatment facility, where you will typically stay from 30 to 90 days, but may last longer if necessary. Treatment includes therapeutic interventions, such as:

• Group counseling
• Family therapy
• Individual therapy
• Support groups

Depending on the program, you may attend 12-step meetings or more secular groups. Some programs also offer holistic interventions, such as yoga, meditation, equine therapy and creative arts therapy.

Outpatient addiction treatment is held in a counseling center with a licensed professional. The difference here is that you will not be living at the facility during the treatment process. Rather, you will be living in your home and attending individual and group sessions throughout the week.

With both inpatient and outpatient treatment, your recovery plan will be individualized to tailor to your particular addiction, mental health and needs. Once you complete your addiction treatment program, it’s important to receive ongoing support. Many people recovering from oxycodone addiction benefit from ongoing therapy, sober living communities, 12-step groups like Narcotics Anonymous, or secular groups like SMART Recovery.

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Resources

1. Kalso, E. (2005). Oxycodone. Journal of Pain and Symptom Management, 29(5), 47-56.
2. Sadiq, N.M., Dice, T.J., Mead, T. (2024). Oxycodone. StatPearls Publishing.
3. Kenan, K., Mack, K., & Paulozzi, L. (2012). Trends in prescriptions for oxycodone and other commonly used opioids in the United States, 2000-2010. Open Medicine: A Peer-Reviewed, Independent, Open-Access Journal, 6(2), e41–e47.
4. Daoust, R., Paquet, J., Cournoyer, A., Piette, É., Morris, J., Lessard, J., Castonguay, V., Williamson, D., & Chauny, J.M. (2020). Side effects from opioids used for acute pain after emergency department discharge. The American Journal of Emergency Medicine, 38(4): 695-701.
5. McQueen, K., & Murphy-Oikonen, J. (2016). Neonatal abstinence syndrome. New England Journal of Medicine, 375(25), 2468-2479.
6. Sproule, B., Brands, B., Li, S., & Catz-Biro, L. (2009). Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids. Canadian Family Physician, 55(1), 68-69.
7. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
8. National Institute on Drug Abuse. (2020, July). Drugs, Brain, and Behavior: The Science of Addiction: Drug Misuse and Addiction.
9. Veilleux, J. C., Colvin, P. J., Anderson, J., York, C., & Heinz, A. J. (2010). A review of opioid dependence treatment: pharmacological and psychosocial interventions to treat opioid addiction. Clinical Psychology Review, 30(2), 155-166.

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