Published: 10/7/2025 | Author: Peter Lee

Researchers at the Comprehensive Center for Pain and Addiction in Phoenix and the National Center for Wellness and Recovery in Tulsa have developed a new subatomic approach to stop fentanyl overdoses with a single dose. Their answer lies in NCWR-10, a newly created molecule designed as a new fentanyl overdose treatment.

The need is urgent. Opioid overdoses claimed over 50,000 American lives in 2024. The Drug Enforcement Administration reports that nearly 70% of those deaths involved synthetic opioids—especially fentanyl. Fentanyl’s strength makes it extremely dangerous in which even a trace amount is often fatal. 

While current treatment options like naloxone can reverse overdoses, the protection doesn’t always last long enough.

A Promising New Molecule for Fentanyl Overdose Treatment

Here’s where NCWR-10 steps in. This promising new molecule fights opioid abuse by acting quickly and lasting longer than naloxone. NCWR-10 was originally synthesized by Don Kyle, a leading expert in drug design and CEO of the National Center for Wellness and Recovery in Oklahoma.

From there, it’s off to Arizona where researchers at the Comprehensive Center for Pain and Addiction in the University of Arizona conduct lab tests. Center director Todd Vanderah agrees that a single dose can save lives.

In mouse studies, NCWR-10 restored breathing as quickly as naloxone but for longer. It also acts on opioid receptors that can ease withdrawal symptoms. “This could make the treatment easier for people in crisis,” Vanderah stated. 

A New Tool in the Fight Against Synthetic Opioids

Researchers are also testing NCWR-10 against powerful synthetics such as carfentanil and isotonitazine. Carfentanil is thousands of times stronger than morphine, and the first dose is often lethal. Isotonitazine is equally deadly. Standard treatments can reverse overdoses from these drugs, but only briefly. 

The Tulsa and Phoenix teams hope NCWR-10 can provide longer protection and reduce relapse rates. If their molecule that fights opioid abuse can meet FDA requirements before going on to human trials, NCWR-10 can give medical staff and first responders a greater tool in the fight against the opioid crisis. 

NCWR-10’s future looks promising, but if you or a loved one is struggling with narcotic or opioid addiction, immediate help is available through local NA meetings and treatment programs.

Call 800-934-1582(Sponsored) to get started now.